What it is
TB-500 is a lab-made peptide based on part of thymosin beta-4, a protein the body makes itself, studied in the lab for wound and tissue repair. It is not an approved drug for any animal.
What the research says
No clinical trial in horses has been published, so nobody can say whether it helps a tendon, a ligament or a wound in your horse, or what a safe amount would be.
It is not an approved animal drug, and it is not on the FDA's office-stock list for animal compounding. For tendon and ligament injuries, your vet can offer treatments with equine data behind them: controlled rehab, rescans, PRP, stem cells and shockwave.
The risks
- 1We found no published safety study in horses.
- 2A positive drug test in competition, with penalties for rider and trainer.
- 3No seller shows a lab test, so the vial may not contain what the label says.
- 4Injecting at the yard risks infection, and nobody checks the result.
Who sells it, ranked by proof
3 sellers sell TB-500 for horses. They’re ranked by what they prove, not by what they pay us. A seller with an FDA warning letter stays listed, with the letter under its name. Sellers label these products “for research”; we list them so you can see who proves what’s in the product.
PeptaGen
TB-500 · Vial
First Choice Equine
TB-500 · Vial
First Choice Equine
BPC-TB nasal spray · Nasal spray
Peppets
TB-500 treats · Treats
Peppets
TB-500 vial · Vial
Compare the sellers · How we score sellers · How to read a lab test
BPC-157TB-500how do they compare? Read the side-by-side comparison.
Questions horse owners ask
Is TB-500 safe for horses?
Nobody knows. We found no published safety study in horses, and no horse seller we checked shows a lab test for what it sells. Talk to your vet before you try anything.
Can my horse compete on TB-500?
No. The 2026 FEI list bans synthetic thymosin fragments, and labs can detect TB-500. Check your national federation and racing rules too.
Is it legal to give my horse TB-500?
It is not an approved drug for animals. FDA treats a product sold to treat disease in animals without approval as an unapproved drug, and in November 2024 it warned six sellers of seizure products for dogs and cats on those grounds. We found no FDA action aimed at TB-500 for animals, which is not the same as approval. News in 2026 about compounding TB-500 concerns prescriptions for people. It is not an approval, and it does not cover animals. Competition rules are separate and stricter.
BPC-157 or TB-500 for a tendon?
Neither has been officially tested in horses, so there is no honest answer. Some horse sellers sell them as one blend. What helps tendons heal well, based on equine data, is controlled rehab guided by rescans.
Sources
- PubMed, TB-500 and thymosin beta-4 in horses, clinical trials only: no results, checked 13 Nov 2026. Open
- FEI, 2026 Equine Prohibited Substances List. Open
- Ho ENM et al. Doping control analysis of TB-500 in equine urine and plasma. J Chromatogr A, 2012. Open
- Equine doping controls of thymosin beta 4: a population study. Drug Test Anal, 2025. Open
- FDA, Approved Animal Drug Products (Green Book): TB-500 not listed. Open
- FDA, GFI #256 on compounding animal drugs: TB-500 not on the office-stock list, checked Oct 2026. Open